Industries/ Healthcare & Life Sciences/ Clinical Trials

Clinical Trials on PYRAX

Clinical trials are slow, costly, and dogged by data-integrity and enrollment problems, while participant privacy and site payments add operational drag. PYRAX brings tamper-evident data capture, milestone-based escrow for site and CRO payments, and PYRAX Compute compute-to-data so sponsors can analyze patient-level data across sites without ever centralizing it.

Market size

$59.9B clinical trials market (2024)

Projection

$99.6B by 2032 · ~6.5% CAGR

The market

$2.6B

Avg. cost to bring a drug to market

~80%

Trials failing to meet enrollment targets

dozens

Data queries per patient in a Phase III

large

Share of trial cost in site payments/monitoring

Source: Grand View Research, 2024. Figures are indicative and provided for context.

What's broken today

Source data can be altered or lost, undermining trust in trial outcomes and inviting FDA scrutiny.

Patient recruitment and retention are the top drivers of delay and cost.

Site, investigator, and CRO payments are manual, delayed, and hard to tie to verified milestones.

Sponsors want cross-site analytics but cannot legally or ethically pool raw patient data.

How PYRAX transforms it

Concrete network elements mapped to this business.

Tamper-evident data capture

Every case-report-form entry is committed on-chain, making source data alteration detectable and giving regulators a verifiable audit trail.

On-chain escrow for milestone payments

Site, investigator, and CRO payments release automatically from escrow when enrollment or visit milestones are cryptographically verified.

PYRAX Compute compute-to-data analytics

Sponsors train and run statistical models across sites' private patient data in place, receiving verifiable results without any site exporting identifiable records.

Shielded-by-default participant privacy

Participant identities and PHI remain off-chain as commitments, so enrollment and outcomes are auditable while individuals stay unidentifiable.

Viewing keys for monitors and IRBs

CRAs, IRBs, and regulators receive scoped read-only keys to verify data integrity and consent without broad access to the patient population.

Buildathon: dApp ideas

Ship-ready concepts for clinical trials on PYRAX.

Start building →

TrialLedger

eCRF capture where each entry is a commitment, giving 21 CFR Part 11-grade tamper evidence.

integrityeth_getProofaudit

MilestonePay

Escrow contract auto-releasing site and CRO payments on verified enrollment and visit milestones.

escrowEVMpayments

CohortAI

PYRAX Compute cross-site model training on private patient data with verifiable results and zero data movement.

Computecompute-to-dataAI

eConsentChain

Digital informed-consent with revocable, shielded participant consent receipts.

consentZKpatient

MonitorKey

Remote-monitoring portal for CRAs and IRBs reading integrity metrics via scoped viewing keys.

viewing-keyscomplianceaudit

RecruitMatch

Privacy-preserving eligibility matcher that screens patients against protocols using ZK proofs, never exposing identities.

ZKrecruitmentconsent

AdverseWatch

Tamper-evident adverse-event reporting with instant-finality timestamps for pharmacovigilance.

finalityprovenancesafety

TrialProof

Public results-registry publishing commitment proofs of primary endpoints to combat selective reporting.

integritycommitmenttransparency

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